7B9O
Crystal structure of Retinoic Acid Receptor alpha (RXRA) in complexed with S169 inhibitor
Summary for 7B9O
Entry DOI | 10.2210/pdb7b9o/pdb |
Descriptor | Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2, 3-(5-(3,5-bis(trifluoromethyl)phenyl)-4-phenyloxazol-2-yl)propanoic acid, ... (4 entities in total) |
Functional Keywords | complex, structural genomics, structural genomics consortium, sgc, dna binding protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 27990.34 |
Authors | Ni, X.,Chaikuad, A.,Schierle, S.,Merk, D.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-12-14, release date: 2021-02-10, Last modification date: 2024-01-31) |
Primary citation | Schierle, S.,Chaikuad, A.,Lillich, F.F.,Ni, X.,Woltersdorf, S.,Schallmayer, E.,Renelt, B.,Ronchetti, R.,Knapp, S.,Proschak, E.,Merk, D. Oxaprozin Analogues as Selective RXR Agonists with Superior Properties and Pharmacokinetics. J.Med.Chem., 64:5123-5136, 2021 Cited by PubMed: 33793232DOI: 10.1021/acs.jmedchem.1c00235 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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