7B9O
Crystal structure of Retinoic Acid Receptor alpha (RXRA) in complexed with S169 inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Retinoic acid receptor RXR-alpha | polymer | 230 | 25818.0 | 1 | UniProt (P19793) Pfam (PF00104) | Homo sapiens (Human) | Nuclear receptor subfamily 2 group B member 1,Retinoid X receptor alpha |
| 2 | B (C) | Nuclear receptor coactivator 2 | polymer | 14 | 1743.0 | 1 | UniProt (Q15596) | Homo sapiens | NCoA-2,Class E basic helix-loop-helix protein 75,bHLHe75,Transcriptional intermediary factor 2,hTIF2 |
| 3 | C (A) | 3-(5-(3,5-bis(trifluoromethyl)phenyl)-4-phenyloxazol-2-yl)propanoic acid | non-polymer | 429.3 | 1 | Chemie (T72) | |||
| 4 | D (A) | water | water | 18.0 | 16 | Chemie (HOH) |
Sequence modifications
A: 229 - 456 (UniProt: P19793)
C: 6 - 19 (UniProt: Q15596)
| PDB | External Database | Details |
|---|---|---|
| Ser 227 | - | expression tag |
| Met 228 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Tyr 19 | Ser 699 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 27561.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 429.3 | |
| All* | Total formula weight | 27990.3 |
