7B7S
CDK2/cyclin A2 in complex with 3H-pyrazolo[4,3-f]quinoline-based derivative HSD1368
Summary for 7B7S
Entry DOI | 10.2210/pdb7b7s/pdb |
Descriptor | Cyclin-dependent kinase 2, Cyclin-A2, 7-(3-(trifluoromethyl)-1H-pyrazol-4yl)-3,8,10,11-tetrahydropyrazolo[4,3-f]thiopyrano[3,4-c]quinoline 9-oxide, ... (7 entities in total) |
Functional Keywords | cyclin-dependent kinase, flt3, acute myeloid leukemia, inhibition, cell cycle |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 128646.66 |
Authors | Djukic, S.,Skerlova, J.,Rezacova, P. (deposition date: 2020-12-11, release date: 2021-08-04, Last modification date: 2024-01-31) |
Primary citation | Dayal, N.,Reznickova, E.,Hernandez, D.E.,Perina, M.,Torregrosa-Allen, S.,Elzey, B.D.,Skerlova, J.,Ajani, H.,Djukic, S.,Vojackova, V.,Lepsik, M.,Rezacova, P.,Krystof, V.,Jorda, R.,Sintim, H.O. 3 H -Pyrazolo[4,3- f ]quinoline-Based Kinase Inhibitors Inhibit the Proliferation of Acute Myeloid Leukemia Cells In Vivo. J.Med.Chem., 64:10981-10996, 2021 Cited by PubMed: 34288692DOI: 10.1021/acs.jmedchem.1c00330 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.54 Å) |
Structure validation
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