7AU5
Tubulin-noscapine-analogue-14e complex
Summary for 7AU5
Entry DOI | 10.2210/pdb7au5/pdb |
Descriptor | Tubulin alpha-1B chain, GLYCEROL, (5~{R})-5-[(1~{S})-4,5-dimethoxy-1,3-dihydro-2-benzofuran-1-yl]-~{N}-ethyl-4-methoxy-7,8-dihydro-5~{H}-[1,3]dioxolo[4,5-g]isoquinoline-6-carboxamide, ... (14 entities in total) |
Functional Keywords | cell cycle, tubulin fold, cytoskeleton, microtubule |
Biological source | Rattus norvegicus (Norway rat) More |
Total number of polymer chains | 6 |
Total formula weight | 265204.11 |
Authors | Yong, C.,Devine, S.M.,Abel, A.-C.,Muthiah, D.,Gao, X.,Callaghan, R.,Capuano, B.,Steinmetz, M.O.,Prota, A.E.,Scammels, P.J. (deposition date: 2020-11-02, release date: 2021-07-07, Last modification date: 2024-01-31) |
Primary citation | Yong, C.,Devine, S.M.,Abel, A.C.,Tomlins, S.D.,Muthiah, D.,Gao, X.,Callaghan, R.,Steinmetz, M.O.,Prota, A.E.,Capuano, B.,Scammells, P.J. 1,3-Benzodioxole-Modified Noscapine Analogues: Synthesis, Antiproliferative Activity, and Tubulin-Bound Structure. Chemmedchem, 16:2882-2894, 2021 Cited by PubMed: 34159741DOI: 10.1002/cmdc.202100363 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
Download full validation report