7ADU
Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ440 (compound 5j)
Summary for 7ADU
Entry DOI | 10.2210/pdb7adu/pdb |
Descriptor | Integrase, DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3'), ... (10 entities in total) |
Functional Keywords | integrase, intasome, protein dna complex, insti, drug, hiv, retrovirus, integration, viral protein |
Biological source | Human spumaretrovirus (SFVcpz(hu)) More |
Total number of polymer chains | 4 |
Total formula weight | 102239.39 |
Authors | Pye, V.E.,Cherepanov, P. (deposition date: 2020-09-16, release date: 2021-03-24, Last modification date: 2024-01-31) |
Primary citation | Smith, S.J.,Zhao, X.Z.,Passos, D.O.,Pye, V.E.,Cherepanov, P.,Lyumkis, D.,Burke Jr., T.R.,Hughes, S.H. HIV-1 Integrase Inhibitors with Modifications That Affect Their Potencies against Drug Resistant Integrase Mutants. Acs Infect Dis., 7:1469-1482, 2021 Cited by PubMed: 33686850DOI: 10.1021/acsinfecdis.0c00819 PDB entries with the same primary citation |
Experimental method |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)