7ADU
Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ440 (compound 5j)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Integrase | polymer | 395 | 44456.7 | 2 | UniProt (P14350) Pfam (PF17921) Pfam (PF00665) Pfam (PF18103) | Human spumaretrovirus (SFVcpz(hu)) | Pr125Pol |
| 2 | C (C) | DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3') | polymer | 19 | 5834.8 | 1 | synthetic construct | ||
| 3 | D (D) | DNA (5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3') | polymer | 17 | 5195.4 | 1 | synthetic construct | ||
| 4 | E, F (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | G (A) | ~{N}-[[2,4-bis(fluoranyl)phenyl]methyl]-5-(hydroxymethyl)-1,4-bis(oxidanyl)-2-oxidanylidene-1,8-naphthyridine-3-carboxamide | non-polymer | 377.3 | 1 | Chemie (R7K) | |||
| 6 | H (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 7 | I, J, K, L, M... (A, B, D) | SULFATE ION | non-polymer | 96.1 | 11 | Chemie (SO4) | |||
| 8 | Q, R, S, T, X... (A, B, C) | GLYCEROL | non-polymer | 92.1 | 6 | Chemie (GOL) | |||
| 9 | U (A) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 10 | AA, BA, CA, DA (A, B, C, D) | water | water | 18.0 | 185 | Chemie (HOH) |
Sequence modifications
A, B: 3 - 392 (UniProt: P14350)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Pro -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Cys 1 | - | expression tag |
| Asn 2 | - | expression tag |
| Ser 217 | Gly 968 | variant |
| Gly 218 | Ser 969 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 99943.6 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 2295.8 | |
| All* | Total formula weight | 102239.4 |
