7A8P

Structure of human mitochondrial RNA polymerase in complex with IMT inhibitor.

Summary for 7A8P

Entry DOI	10.2210/pdb7a8p/pdb
EMDB information	11679
Descriptor	DNA-directed RNA polymerase, mitochondrial, (3~{R})-1-[(2~{R})-2-[4-(2-chloranyl-4-fluoranyl-phenyl)-2-oxidanylidene-chromen-7-yl]oxypropanoyl]piperidine-3-carboxylic acid (2 entities in total)
Functional Keywords	mitochondria, transcription, polymerase, inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	130276.97
Authors	Hillen, H.S.,Bonekamp, N.,Peter, B.,Felser, A.,Bergbrede, T.,Choidas, A.,Horn, M.,Unger, A.,di Lucrezia, R.,Atanassov, I.,Li, X.,Koch, U.,Menninger, S.,Boros, J.,Habenberger, P.,Giavalisco, P.,Cramer, P.,Denzel, M.,Nussbaumer, P.,Klebl, B.,Falkenberg, M.,Gustafsson, C.M.,Larsson, N.G. (deposition date: 2020-08-30, release date: 2020-12-30, Last modification date: 2024-05-01)
Primary citation	Bonekamp, N.A.,Peter, B.,Hillen, H.S.,Felser, A.,Bergbrede, T.,Choidas, A.,Horn, M.,Unger, A.,Di Lucrezia, R.,Atanassov, I.,Li, X.,Koch, U.,Menninger, S.,Boros, J.,Habenberger, P.,Giavalisco, P.,Cramer, P.,Denzel, M.S.,Nussbaumer, P.,Klebl, B.,Falkenberg, M.,Gustafsson, C.M.,Larsson, N.G. Small-molecule inhibitors of human mitochondrial DNA transcription. Nature, 588:712-716, 2020 Cited by PubMed: 33328633 DOI: 10.1038/s41586-020-03048-z PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.5 Å)

Structure validation