7A8P

Structure of human mitochondrial RNA polymerase in complex with IMT inhibitor.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	DNA-directed RNA polymerase, mitochondrial	polymer	1143	129803.1	1	UniProt (O00411) Pfam (PF14700) Pfam (PF00940)	Homo sapiens (Human)	MtRPOL
2	B (A)	(3~{R})-1-[(2~{R})-2-[4-(2-chloranyl-4-fluoranyl-phenyl)-2-oxidanylidene-chromen-7-yl]oxypropanoyl]piperidine-3-carboxylic acid	non-polymer		473.9	1	Chemie (R4Q)

Sequence modifications

A: 105 - 1230 (UniProt: O00411)

PDB	External Database	Details
Met 88	-	initiating methionine
Gly 89	-	expression tag
His 90	-	expression tag
His 91	-	expression tag
His 92	-	expression tag
His 93	-	expression tag
His 94	-	expression tag
His 95	-	expression tag
Glu 96	-	expression tag
Asn 97	-	expression tag
Leu 98	-	expression tag
Tyr 99	-	expression tag
Phe 100	-	expression tag
Gln 101	-	expression tag
Ser 102	-	expression tag
Asn 103	-	expression tag
Ala 104	-	expression tag
Ala 555	Glu 555	variant

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	129803.1
Non-Polymers*	Number of molecules	1
	Total formula weight	473.9
All*	Total formula weight	130277.0

*Water molecules are not included.