7A8P
Structure of human mitochondrial RNA polymerase in complex with IMT inhibitor.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000175 | molecular_function | 3'-5'-RNA exonuclease activity |
| A | 0001018 | molecular_function | mitochondrial promoter sequence-specific DNA binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003899 | molecular_function | DNA-directed RNA polymerase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0006264 | biological_process | mitochondrial DNA replication |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0006390 | biological_process | mitochondrial transcription |
| A | 0006391 | biological_process | transcription initiation at mitochondrial promoter |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0034062 | molecular_function | 5'-3' RNA polymerase activity |
| A | 0034245 | cellular_component | mitochondrial DNA-directed RNA polymerase complex |
| A | 0042645 | cellular_component | mitochondrial nucleoid |
| A | 0043565 | molecular_function | sequence-specific DNA binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | binding site for residue R4Q A 1301 |
| Chain | Residue |
| A | VAL709 |
| A | PHE813 |
| A | HIS815 |
| A | LEU816 |
| A | SER818 |
| A | VAL820 |
| A | ALA821 |
| A | LEU824 |
| A | LEU825 |
| A | PRO732 |
| A | LEU775 |
| A | GLU778 |
| A | ALA779 |
| A | ARG782 |
| A | ALA786 |
| A | LEU789 |
| A | HIS812 |
Functional Information from PROSITE/UniProt
| site_id | PS00489 |
| Number of Residues | 15 |
| Details | RNA_POL_PHAGE_2 Bacteriophage-type RNA polymerase family active site signature 2. ItRkvvKqtVMTvvY |
| Chain | Residue | Details |
| A | ILE985-TYR999 |
| site_id | PS00900 |
| Number of Residues | 12 |
| Details | RNA_POL_PHAGE_1 Bacteriophage-type RNA polymerase family active site signature 1. PVhqDGSCNGLQ |
| Chain | Residue | Details |
| A | PRO918-GLN929 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
