7A5V
CryoEM structure of a human gamma-aminobutyric acid receptor, the GABA(A)R-beta3 homopentamer, in complex with histamine and megabody Mb25 in lipid nanodisc
Summary for 7A5V
Entry DOI | 10.2210/pdb7a5v/pdb |
Related | 4COF |
EMDB information | 11657 |
Descriptor | Gamma-aminobutyric acid receptor subunit beta-3,Gamma-aminobutyric acid receptor subunit beta-3, CHLORIDE ION, Megabody Mb25, ... (11 entities in total) |
Functional Keywords | pentameric ligand-gated ion channel, neurotrasmitter receptor, gaba(a) receptor, membrane protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 104693.20 |
Authors | Nakane, T.,Kotecha, A.,Sente, A.,Yamashita, K.,McMullan, G.,Masiulis, S.,Brown, P.M.G.E.,Grigoras, I.T.,Malinauskaite, L.,Malinauskas, T.,Miehling, J.,Yu, L.,Karia, D.,Pechnikova, E.V.,de Jong, E.,Keizer, J.,Bischoff, M.,McCormack, J.,Tiemeijer, P.,Hardwick, S.W.,Chirgadze, D.Y.,Murshudov, G.,Aricescu, A.R.,Scheres, S.H.W. (deposition date: 2020-08-22, release date: 2020-11-18, Last modification date: 2020-11-25) |
Primary citation | Nakane, T.,Kotecha, A.,Sente, A.,McMullan, G.,Masiulis, S.,Brown, P.M.G.E.,Grigoras, I.T.,Malinauskaite, L.,Malinauskas, T.,Miehling, J.,Uchanski, T.,Yu, L.,Karia, D.,Pechnikova, E.V.,de Jong, E.,Keizer, J.,Bischoff, M.,McCormack, J.,Tiemeijer, P.,Hardwick, S.W.,Chirgadze, D.Y.,Murshudov, G.,Aricescu, A.R.,Scheres, S.H.W. Single-particle cryo-EM at atomic resolution. Nature, 587:152-156, 2020 Cited by PubMed: 33087931DOI: 10.1038/s41586-020-2829-0 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (1.7 Å) |
Structure validation
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