6ZZ4

Crystal structure of the PTPN2 C216G mutant

6ZZ4 の概要

• エントリーDOI: 10.2210/pdb6zz4/pdb
• 分子名称: Tyrosine-protein phosphatase non-receptor type 2, PHOSPHATE ION (3 entities in total)
• 機能のキーワード: phosphatase, signaling protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 73794.78

構造登録者

Mechaly, A.E.,Berthelet, J.,Nian, Q.,Parlato, M.,Cerf-Bensussan, N.,Haouz, A.,Rodrigues-Lima, F. (登録日: 2020-08-03, 公開日: 2021-08-18, 最終更新日: 2024-01-31)

• 主引用文献: Nian, Q.,Berthelet, J.,Parlato, M.,Mechaly, A.E.,Liu, R.,Dupret, J.M.,Cerf-Bensussan, N.,Haouz, A.,Rodrigues Lima, F.; Structural characterization of a pathogenic mutant of human protein tyrosine phosphatase PTPN2 (Cys216Gly) that causes very early onset autoimmune enteropathy.; Protein Sci., 31:538-544, 2022; PubMed: 34806245; DOI: 10.1002/pro.4246

実験手法

X-RAY DIFFRACTION (2.43 Å)