6ZYU

Structure of the GluA2 ligand-binding domain (L483Y-N754S) in complex with glutamate and BPAM549

6ZYU の概要

• エントリーDOI: 10.2210/pdb6zyu/pdb
• 分子名称: Glutamate receptor 2,Glutamate receptor 2, ZINC ION, CACODYLATE ION, ... (10 entities in total)
• 機能のキーワード: glua2-lbd, glua2-s1s2j, ampa receptor, ligand-binding domain, positive allosteric modulator, membrane protein, l483y, n754s, signaling protein
• 由来する生物種: Rattus norvegicus (Rat); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 91473.65

構造登録者

Dorosz, J.,Christensen, K.M.,Kastrup, J.S. (登録日: 2020-08-03, 公開日: 2021-08-11, 最終更新日: 2024-01-31)

• 主引用文献: Etse, K.S.,Dorosz, J.,McLain Christensen, K.,Thomas, J.Y.,Botez Pop, I.,Goffin, E.,Colson, T.,Lestage, P.,Danober, L.,Pirotte, B.,Kastrup, J.S.,Francotte, P.; Development of Thiochroman Dioxide Analogues of Benzothiadiazine Dioxides as New Positive Allosteric Modulators of alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors.; Acs Chem Neurosci, 12:2679-2692, 2021; PubMed: 34242002; DOI: 10.1021/acschemneuro.1c00255

実験手法

X-RAY DIFFRACTION (1.9 Å)