6ZXO

Crystal structure of His-tagged human thymidylate synthase (HT-hTS) in complex with FdUMP and Raltitrexed (Tomudex)

6ZXO の概要

• エントリーDOI: 10.2210/pdb6zxo/pdb
• 分子名称: Thymidylate synthase, TOMUDEX, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, ... (6 entities in total)
• 機能のキーワード: human thymidylate synthase, hts, active conformation, fdump, ratitrexed, tomudex, methyltransferase, transferase, folate pathway
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 227981.00

構造登録者

Pozzi, C.,Mangani, S. (登録日: 2020-07-30, 公開日: 2021-05-19, 最終更新日: 2024-01-31)

• 主引用文献: Pozzi, C.,Santucci, M.,Marverti, G.,D'Arca, D.,Tagliazucchi, L.,Ferrari, S.,Gozzi, G.,Losi, L.,Tassone, G.,Mangani, S.,Ponterini, G.,Costi, M.P.; Structural Bases for the Synergistic Inhibition of Human Thymidylate Synthase and Ovarian Cancer Cell Growth by Drug Combinations.; Cancers (Basel), 13:-, 2021; PubMed: 33923290; DOI: 10.3390/cancers13092061

実験手法

X-RAY DIFFRACTION (2.6 Å)