6ZXI

Crystal Structure of the OXA-48 Carbapenem-Hydrolyzing Class D beta-Lactamase in Complex with the DBO inhibitor ANT3310

Summary for 6ZXI

• Entry DOI: 10.2210/pdb6zxi/pdb
• Descriptor: Beta-lactamase, [[(3~{R},6~{R})-6-fluoranyl-1-methanoyl-piperidin-3-yl]amino] hydrogen sulfate, 1,2-ETHANEDIOL, ... (6 entities in total)
• Functional Keywords: beta-lactamase, carbapenemase, ant3310, antibiotic resistance, carbapenem-hydrolyzing beta-lactamase, hydrolase, diazabicyclooctanone inhibitor
• Biological source: Klebsiella pneumoniae
• Total number of polymer chains: 2
• Total formula weight: 61481.49

Authors

Docquier, J.D.,Pozzi, C.,De Luca, F.,Benvenuti, M.,Mangani, S. (deposition date: 2020-07-29, release date: 2021-08-11, Last modification date: 2024-02-07)

• Primary citation: Davies, D.T.,Leiris, S.,Zalacain, M.,Sprynski, N.,Castandet, J.,Bousquet, J.,Lozano, C.,Llanos, A.,Alibaud, L.,Vasa, S.,Pattipati, R.,Valige, R.,Kummari, B.,Pothukanuri, S.,De Piano, C.,Morrissey, I.,Holden, K.,Warn, P.,Marcoccia, F.,Benvenuti, M.,Pozzi, C.,Tassone, G.,Mangani, S.,Docquier, J.D.,Pallin, D.,Elliot, R.,Lemonnier, M.,Everett, M.; Discovery of ANT3310 , a Novel Broad-Spectrum Serine beta-Lactamase Inhibitor of the Diazabicyclooctane Class, Which Strongly Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacterales and Acinetobacter baumannii.; J.Med.Chem., 63:15802-15820, 2020; PubMed: 33306385; DOI: 10.1021/acs.jmedchem.0c01535

Experimental method

X-RAY DIFFRACTION (1.85 Å)