6ZWK

Crystal structure of the phosphorylated C-terminal tail of histone H2AX in complex with a specific nanobody (C6 gammaXbody)

6ZWK の概要

• エントリーDOI: 10.2210/pdb6zwk/pdb
• 分子名称: gammaXbody, Histone H2AX, SODIUM ION, ... (5 entities in total)
• 機能のキーワード: nanobody, phosphopeptide-recognition protein, gamma-h2ax, immune system
• 由来する生物種: Vicugna pacos (alpaca); 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 106914.98

構造登録者

McEwen, A.G.,Moeglin, E.,Desplancq, D.,Weiss, E.,Poterszman, A. (登録日: 2020-07-28, 公開日: 2021-07-21, 最終更新日: 2024-01-31)

• 主引用文献: Moeglin, E.,Desplancq, D.,Stoessel, A.,Massute, C.,Ranniger, J.,McEwen, A.G.,Zeder-Lutz, G.,Oulad-Abdelghani, M.,Chiper, M.,Lafaye, P.,Di Ventura, B.,Didier, P.,Poterszman, A.,Weiss, E.; A Novel Nanobody Precisely Visualizes Phosphorylated Histone H2AX in Living Cancer Cells under Drug-Induced Replication Stress.; Cancers (Basel), 13:-, 2021; PubMed: 34282773; DOI: 10.3390/cancers13133317

実験手法

X-RAY DIFFRACTION (1.55 Å)