6ZTR

Crystal Structure of the anti-human P-Cadherin Fab CQY684 in complex with human P-Cadherin(108-324)

Summary for 6ZTR

• Entry DOI: 10.2210/pdb6ztr/pdb
• Related: 6ZTB 6ZTF
• Descriptor: CQY684 Fab heavy-chain, CQY684 Fab light-chain, Cadherin-3, ... (5 entities in total)
• Functional Keywords: immunoglobulin cell adhesion, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 6
• Total formula weight: 147357.36

Authors

Rondeau, J.M.,Lehmann, S. (deposition date: 2020-07-20, release date: 2021-05-05, Last modification date: 2024-01-31)

• Primary citation: Sheng, Q.,D'Alessio, J.A.,Menezes, D.L.,Karim, C.,Tang, Y.,Tam, A.,Clark, S.,Ying, C.,Connor, A.,Mansfield, K.G.,Rondeau, J.M.,Ghoddusi, M.,Geyer, F.C.,Gu, J.,McLaughlin, M.E.,Newcombe, R.,Elliot, G.,Tschantz, W.R.,Lehmann, S.,Fanton, C.P.,Miller, K.,Huber, T.,Rendahl, K.G.,Jeffry, U.,Pryer, N.K.,Lees, E.,Kwon, P.,Abraham, J.A.,Damiano, J.S.,Abrams, T.J.; PCA062, a P-cadherin Targeting Antibody-Drug Conjugate, Displays Potent Antitumor Activity Against P-cadherin-expressing Malignancies.; Mol.Cancer Ther., 20:1270-1282, 2021; PubMed: 33879555; DOI: 10.1158/1535-7163.MCT-20-0708

Experimental method

X-RAY DIFFRACTION (2.1 Å)