6ZTF
Crystal Structure of the anti-human P-Cadherin Fab CQY684
Summary for 6ZTF
Entry DOI | 10.2210/pdb6ztf/pdb |
Related | 6ZTB |
Descriptor | CQY684 Fab heavy-chain, CQY684 Fab light-chain (3 entities in total) |
Functional Keywords | immunoglobulin, fab, immune system |
Biological source | Homo sapiens More |
Total number of polymer chains | 4 |
Total formula weight | 99398.19 |
Authors | Rondeau, J.M.,Lehmann, S. (deposition date: 2020-07-20, release date: 2021-05-05, Last modification date: 2024-01-31) |
Primary citation | Sheng, Q.,D'Alessio, J.A.,Menezes, D.L.,Karim, C.,Tang, Y.,Tam, A.,Clark, S.,Ying, C.,Connor, A.,Mansfield, K.G.,Rondeau, J.M.,Ghoddusi, M.,Geyer, F.C.,Gu, J.,McLaughlin, M.E.,Newcombe, R.,Elliot, G.,Tschantz, W.R.,Lehmann, S.,Fanton, C.P.,Miller, K.,Huber, T.,Rendahl, K.G.,Jeffry, U.,Pryer, N.K.,Lees, E.,Kwon, P.,Abraham, J.A.,Damiano, J.S.,Abrams, T.J. PCA062, a P-cadherin Targeting Antibody-Drug Conjugate, Displays Potent Antitumor Activity Against P-cadherin-expressing Malignancies. Mol.Cancer Ther., 20:1270-1282, 2021 Cited by PubMed: 33879555DOI: 10.1158/1535-7163.MCT-20-0708 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
Download full validation report