6ZTB

Crystal Structure of human P-Cadherin EC1_EC2

Summary for 6ZTB

Entry DOI	10.2210/pdb6ztb/pdb
Descriptor	Cadherin-3, CALCIUM ION, SODIUM ION, ... (4 entities in total)
Functional Keywords	calcium, cell membrane, glycoprotein, cell adhesion
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	24071.55
Authors	Rondeau, J.M.,Lehmann, S. (deposition date: 2020-07-17, release date: 2021-05-05, Last modification date: 2024-01-31)
Primary citation	Sheng, Q.,D'Alessio, J.A.,Menezes, D.L.,Karim, C.,Tang, Y.,Tam, A.,Clark, S.,Ying, C.,Connor, A.,Mansfield, K.G.,Rondeau, J.M.,Ghoddusi, M.,Geyer, F.C.,Gu, J.,McLaughlin, M.E.,Newcombe, R.,Elliot, G.,Tschantz, W.R.,Lehmann, S.,Fanton, C.P.,Miller, K.,Huber, T.,Rendahl, K.G.,Jeffry, U.,Pryer, N.K.,Lees, E.,Kwon, P.,Abraham, J.A.,Damiano, J.S.,Abrams, T.J. PCA062, a P-cadherin Targeting Antibody-Drug Conjugate, Displays Potent Antitumor Activity Against P-cadherin-expressing Malignancies. Mol.Cancer Ther., 20:1270-1282, 2021 Cited by PubMed: 33879555 DOI: 10.1158/1535-7163.MCT-20-0708 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation