6ZIE

Crystal structure of MCL-1 in complex with a neutralizing Alphabody CMPX-383B

Summary for 6ZIE

Entry DOI	10.2210/pdb6zie/pdb
Descriptor	CMPX-383B, Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION, ... (4 entities in total)
Functional Keywords	de novo protein design, 3 helical antiparallel coiled coil, cell penetrating alphabody mcl-1 neutralizing alphabody, antitumor protein
Biological source	synthetic construct More
Total number of polymer chains	2
Total formula weight	33627.94
Authors	Pannecoucke, E.,Savvides, S.N.,Desmet, J.,Lasters, I. (deposition date: 2020-06-25, release date: 2021-04-28, Last modification date: 2024-01-31)
Primary citation	Pannecoucke, E.,Van Trimpont, M.,Desmet, J.,Pieters, T.,Reunes, L.,Demoen, L.,Vuylsteke, M.,Loverix, S.,Vandenbroucke, K.,Alard, P.,Henderikx, P.,Deroo, S.,Baatz, F.,Lorent, E.,Thiolloy, S.,Somers, K.,McGrath, Y.,Van Vlierberghe, P.,Lasters, I.,Savvides, S.N. Cell-penetrating Alphabody protein scaffolds for intracellular drug targeting. Sci Adv, 7:-, 2021 Cited by PubMed: 33771865 DOI: 10.1126/sciadv.abe1682 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation