6ZIE
Crystal structure of MCL-1 in complex with a neutralizing Alphabody CMPX-383B
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | CMPX-383B | polymer | 143 | 14950.1 | 1 | synthetic construct | ||
2 | B | Induced myeloid leukemia cell differentiation protein Mcl-1 | polymer | 162 | 18350.8 | 1 | UniProt (Q07820) Pfam (PF00452) In PDB | Homo sapiens (Human) | Bcl-2-like protein 3,Bcl2-L-3,Bcl-2-related protein EAT/mcl1,mcl1/EAT |
3 | A, B | ZINC ION | non-polymer | 65.4 | 5 | Chemie (ZN) | |||
4 | water | water | 18.0 | 31 | Chemie (HOH) |
Sequence modifications
B: 172 - 327 (UniProt: Q07820)
PDB | External Database | Details |
---|---|---|
Gly 166 | - | expression tag |
Ser 167 | - | expression tag |
His 168 | - | expression tag |
Met 169 | - | expression tag |
Gly 170 | - | expression tag |
Ser 171 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 33300.9 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 327.0 | |
All* | Total formula weight | 33627.9 |