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6ZGX

Structure of human galactokinase 1 bound with 2-(4-chlorophenyl)-N-(pyrimidin-2-yl)acetamide

Summary for 6ZGX
Entry DOI10.2210/pdb6zgx/pdb
DescriptorGalactokinase, beta-D-galactopyranose, 2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclohexane]-5-one, ... (5 entities in total)
Functional Keywordsgalk1, galactokinase 1, fragment screening, allosteric fragment, binding hotspt, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains4
Total formula weight174250.91
Authors
Mackinnon, S.R.,Bezerra, G.A.,Zhang, M.,Foster, W.,Krojer, T.,Brandao-Neto, J.,Douangamath, A.,Arrowsmith, C.,Edwards, A.,Bountra, C.,Brennan, P.,Lai, K.,Yue, W.W. (deposition date: 2020-06-20, release date: 2020-07-29, Last modification date: 2024-01-24)
Primary citationMackinnon, S.R.,Krojer, T.,Foster, W.R.,Diaz-Saez, L.,Tang, M.,Huber, K.V.M.,von Delft, F.,Lai, K.,Brennan, P.E.,Arruda Bezerra, G.,Yue, W.W.
Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia.
Acs Chem.Biol., 16:586-595, 2021
Cited by
PubMed: 33724769
DOI: 10.1021/acschembio.0c00498
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.86 Å)
Structure validation

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