6ZGX
Structure of human galactokinase 1 bound with 2-(4-chlorophenyl)-N-(pyrimidin-2-yl)acetamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, D, E) | Galactokinase | polymer | 399 | 43103.0 | 4 | UniProt (P51570) Pfam (PF10509) Pfam (PF00288) Pfam (PF08544) | Homo sapiens (Human) | Galactose kinase |
| 2 | E, G, J (A, B, E) | beta-D-galactopyranose | non-polymer | 180.2 | 3 | Chemie (GAL) | |||
| 3 | F, H, K (A, B, E) | 2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclohexane]-5-one | non-polymer | 350.4 | 3 | Chemie (HFK) | |||
| 4 | I (D) | 1-[2-(2-oxidanylidenepyrrolidin-1-yl)ethyl]-3-phenyl-urea | non-polymer | 247.3 | 1 | Chemie (S6V) | |||
| 5 | L, M, N, O (A, B, D, E) | water | water | 18.0 | 456 | Chemie (HOH) |
Sequence modifications
A, B, D, E: 2 - 392 (UniProt: P51570)
| PDB | External Database | Details |
|---|---|---|
| Met -6 | - | initiating methionine |
| Ala -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| His 0 | - | expression tag |
| His 1 | - | expression tag |
| Ala 252 | Lys 252 | engineered mutation |
| Ala 253 | Glu 253 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 172411.9 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1839.0 | |
| All* | Total formula weight | 174250.9 |
