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6ZGC

Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound Saracatinib (AZD0530)

Summary for 6ZGC
Entry DOI10.2210/pdb6zgc/pdb
DescriptorActivin receptor type I, N-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-7-[2-(4-METHYLPIPERAZIN-1-YL)ETHOXY]-5-(TETRAHYDRO-2H-PYRAN-4-YLOXY)QUINAZOLIN-4-AMINE, POTASSIUM ION, ... (5 entities in total)
Functional Keywordsinhibitor complex. kinase. type i receptor, bmp, signalling., signaling protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains4
Total formula weight141994.56
Authors
Williams, E.P.,Galan Bartual, S.,Burgess-Brown, N.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.N. (deposition date: 2020-06-18, release date: 2020-07-29, Last modification date: 2024-01-24)
Primary citationWilliams, E.,Bagarova, J.,Kerr, G.,Xia, D.D.,Place, E.S.,Dey, D.,Shen, Y.,Bocobo, G.A.,Mohedas, A.H.,Huang, X.,Sanderson, P.E.,Lee, A.,Zheng, W.,Economides, A.N.,Smith, J.C.,Yu, P.B.,Bullock, A.N.
Saracatinib is an efficacious clinical candidate for fibrodysplasia ossificans progressiva.
JCI Insight, 6:-, 2021
Cited by
PubMed: 33705358
DOI: 10.1172/jci.insight.95042
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.67 Å)
Structure validation

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