6ZGC
Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound Saracatinib (AZD0530)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Activin receptor type I | polymer | 301 | 34537.6 | 4 | UniProt (Q04771) Pfam (PF00069) | Homo sapiens (Human) | |
| 2 | E, K, Q, W (A, B, C, D) | N-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-7-[2-(4-METHYLPIPERAZIN-1-YL)ETHOXY]-5-(TETRAHYDRO-2H-PYRAN-4-YLOXY)QUINAZOLIN-4-AMINE | non-polymer | 542.0 | 4 | Chemie (H8H) | |||
| 3 | F, L, R, X (A, B, C, D) | POTASSIUM ION | non-polymer | 39.1 | 4 | Chemie (K) | |||
| 4 | AA, BA, G, H, I... (D, A, B, C) | PHOSPHATE ION | non-polymer | 95.0 | 16 | Chemie (PO4) | |||
| 5 | CA, DA, EA, FA (A, B, C, D) | water | water | 18.0 | 20 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 201 - 499 (UniProt: Q04771)
| PDB | External Database | Details |
|---|---|---|
| Ser 199 | - | expression tag |
| Met 200 | - | expression tag |
| Asp 207 | Gln 207 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 138150.5 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 3844.0 | |
| All* | Total formula weight | 141994.6 |
