6ZEX
Keap1 kelch domain bound to a small molecule fragment
Summary for 6ZEX
Entry DOI | 10.2210/pdb6zex/pdb |
Descriptor | Kelch-like ECH-associated protein 1, DIMETHYL SULFOXIDE, 5-cyclopropyl-1-phenyl-pyrazole-4-carboxylic acid, ... (4 entities in total) |
Functional Keywords | keap1, nrf2, oxidative stress, small molecule complex, peptide binding protein |
Biological source | Mus musculus (House mouse) |
Total number of polymer chains | 1 |
Total formula weight | 34059.34 |
Authors | Narayanan, D.,Bach, A.,Gajhede, M. (deposition date: 2020-06-16, release date: 2021-04-14, Last modification date: 2024-01-24) |
Primary citation | Pallesen, J.S.,Narayanan, D.,Tran, K.T.,Solbak, S.M.O.,Marseglia, G.,Sorensen, L.M.E.,Hoj, L.J.,Munafo, F.,Carmona, R.M.C.,Garcia, A.D.,Desu, H.L.,Brambilla, R.,Johansen, T.N.,Popowicz, G.M.,Sattler, M.,Gajhede, M.,Bach, A. Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds. J.Med.Chem., 64:4623-4661, 2021 Cited by PubMed: 33818106DOI: 10.1021/acs.jmedchem.0c02094 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.98 Å) |
Structure validation
Download full validation report