6ZBO
HIF Prolyl Hydroxylase 2 (PHD2/EGLN1) in Complex with 1-(6-morpholinopyrimidin-4-yl)-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-5-ol (Molidustat)
Summary for 6ZBO
Entry DOI | 10.2210/pdb6zbo/pdb |
Descriptor | Egl nine homolog 1, MANGANESE (II) ION, 2-(6-morpholin-4-ylpyrimidin-4-yl)-4-(1,2,3-triazol-1-yl)pyrazol-3-ol, ... (5 entities in total) |
Functional Keywords | phd2, inhibitor, complex, molidustat, oxidoreductase, hif |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 6 |
Total formula weight | 155466.07 |
Authors | Figg Jr, W.D.,McDonough, M.A.,Nakashima, Y.,Holt-Martyn, J.P.,Schofield, C.J. (deposition date: 2020-06-08, release date: 2021-04-07, Last modification date: 2024-01-24) |
Primary citation | Figg Jr., W.D.,McDonough, M.A.,Chowdhury, R.,Nakashima, Y.,Zhang, Z.,Holt-Martyn, J.P.,Krajnc, A.,Schofield, C.J. Structural Basis of Prolyl Hydroxylase Domain Inhibition by Molidustat. Chemmedchem, 16:2082-2088, 2021 Cited by PubMed: 33792169DOI: 10.1002/cmdc.202100133 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.79 Å) |
Structure validation
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