6ZBN
HIF Prolyl Hydroxylase 2 (PHD2/EGLN1) in complex with tert-butyl 6-(5-hydroxy-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-1-yl)nicotinate (IOX4)
Summary for 6ZBN
Entry DOI | 10.2210/pdb6zbn/pdb |
Descriptor | Egl nine homolog 1, ~{tert}-butyl 6-[5-oxidanyl-4-(1,2,3-triazol-1-yl)pyrazol-1-yl]pyridine-3-carboxylate, MANGANESE (II) ION, ... (5 entities in total) |
Functional Keywords | inhibitor, complex, oxidoreductase, iox4, hif, phd2, hypoxia |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 6 |
Total formula weight | 155181.41 |
Authors | Figg Jr, W.D.,McDonough, M.A.,Nakashima, Y.,Schofield, C.J. (deposition date: 2020-06-08, release date: 2021-04-07, Last modification date: 2024-01-24) |
Primary citation | Figg Jr., W.D.,McDonough, M.A.,Chowdhury, R.,Nakashima, Y.,Zhang, Z.,Holt-Martyn, J.P.,Krajnc, A.,Schofield, C.J. Structural Basis of Prolyl Hydroxylase Domain Inhibition by Molidustat. Chemmedchem, 16:2082-2088, 2021 Cited by PubMed: 33792169DOI: 10.1002/cmdc.202100133 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.01 Å) |
Structure validation
Download full validation report