6Z4D

Crystal Structure of EGFR-T790M/V948R in Complex with Mavelertinib and EAI001

Summary for 6Z4D

Entry DOI	10.2210/pdb6z4d/pdb
Descriptor	Epidermal growth factor receptor, N-[(3R,4R)-4-fluoro-1-{6-[(3-methoxy-1-methyl-1H-pyrazol-4-yl)amino]-9-methyl-9H-purin-2-yl}pyrrolidin-3-yl]propanamide, SULFATE ION, ... (5 entities in total)
Functional Keywords	egfr, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	77592.42
Authors	Niggenaber, J.,Mueller, M.P.,Rauh, D. (deposition date: 2020-05-25, release date: 2020-11-11, Last modification date: 2024-01-24)
Primary citation	Niggenaber, J.,Heyden, L.,Grabe, T.,Muller, M.P.,Lategahn, J.,Rauh, D. Complex Crystal Structures of EGFR with Third-Generation Kinase Inhibitors and Simultaneously Bound Allosteric Ligands. Acs Med.Chem.Lett., 11:2484-2490, 2020 Cited by PubMed: 33335671 DOI: 10.1021/acsmedchemlett.0c00472 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation