6Z4D
Crystal Structure of EGFR-T790M/V948R in Complex with Mavelertinib and EAI001
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Epidermal growth factor receptor | polymer | 333 | 37963.9 | 2 | UniProt (P00533) Pfam (PF07714) In PDB | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
2 | A, B | N-[(3R,4R)-4-fluoro-1-{6-[(3-methoxy-1-methyl-1H-pyrazol-4-yl)amino]-9-methyl-9H-purin-2-yl}pyrrolidin-3-yl]propanamide | non-polymer | 417.4 | 2 | Chemie (8BS) | |||
3 | A, B | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
4 | B | (2R)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)-2-phenyl-N-(1,3-thiazol-2-yl)acetamide | non-polymer | 349.4 | 1 | Chemie (57N) | |||
5 | water | water | 18.0 | 174 | Chemie (HOH) |
Sequence modifications
A, B: 695 - 1022 (UniProt: P00533)
PDB | External Database | Details |
---|---|---|
Gly 690 | - | expression tag |
Ser 691 | - | expression tag |
His 692 | - | expression tag |
Met 693 | - | expression tag |
Ala 694 | - | expression tag |
Met 790 | Thr 790 | engineered mutation |
Arg 948 | Val 948 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 75927.8 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 1664.6 | |
All* | Total formula weight | 77592.4 |