6Z4D
Crystal Structure of EGFR-T790M/V948R in Complex with Mavelertinib and EAI001
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Epidermal growth factor receptor | polymer | 333 | 37963.9 | 2 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | C, F (A, B) | N-[(3R,4R)-4-fluoro-1-{6-[(3-methoxy-1-methyl-1H-pyrazol-4-yl)amino]-9-methyl-9H-purin-2-yl}pyrrolidin-3-yl]propanamide | non-polymer | 417.4 | 2 | Chemie (8BS) | |||
| 3 | D, E, H, I, J (A, B) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 4 | G (B) | (2R)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)-2-phenyl-N-(1,3-thiazol-2-yl)acetamide | non-polymer | 349.4 | 1 | Chemie (57N) | |||
| 5 | K, L (A, B) | water | water | 18.0 | 174 | Chemie (HOH) |
Sequence modifications
A, B: 695 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 690 | - | expression tag |
| Ser 691 | - | expression tag |
| His 692 | - | expression tag |
| Met 693 | - | expression tag |
| Ala 694 | - | expression tag |
| Met 790 | Thr 790 | engineered mutation |
| Arg 948 | Val 948 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 75927.8 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1664.6 | |
| All* | Total formula weight | 77592.4 |
