6Z3L

Repulsive Guidance Molecule C (RGMC, Hemojuvelin, HJV, HFE2) in complex with Growth Differentiation Factor 5 (GDF5)

6Z3L の概要

• エントリーDOI: 10.2210/pdb6z3l/pdb
• 関連するPDBエントリー: 6Z3G 6Z3H 6Z3J
• 分子名称: Growth/differentiation factor 5, Hemojuvelin (3 entities in total)
• 機能のキーワード: repulsive guidance molecule, rgm, bone morphogenetic protein, bmp, growth differentiation factor 5, gdf5, neogenin, axon guidance, tgfbeta signalling, brain development, iron metabolism, hemojuvelin, hjv, hfe2, hemochromatosis type 2 protein, juvenile hemochromatosis., signaling protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 25807.47

構造登録者

Malinauskas, T.,Peer, T.V.,Bishop, B.,Muller, T.D.,Siebold, C. (登録日: 2020-05-20, 公開日: 2020-07-01, 最終更新日: 2024-01-24)

• 主引用文献: Malinauskas, T.,Peer, T.V.,Bishop, B.,Mueller, T.D.,Siebold, C.; Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex.; Proc.Natl.Acad.Sci.USA, 117:15620-15631, 2020; PubMed: 32576689; DOI: 10.1073/pnas.2000561117

実験手法

X-RAY DIFFRACTION (2.513 Å)