6Z1A

Ternary complex of Staphylococcus aureus DNA gyrase with AMK12 and DNA

Summary for 6Z1A

• Entry DOI: 10.2210/pdb6z1a/pdb
• Descriptor: DNA gyrase subunit B,DNA gyrase subunit A, DNA (5'-D(*AP*GP*CP*CP*GP*TP*AP*G)-3'), DNA (5'-D(P*GP*TP*AP*CP*CP*TP*AP*CP*GP*GP*CP*T)-3'), ... (9 entities in total)
• Functional Keywords: type iia topoisomerase, antibacterial, inhibitor, isomerase, fusion protein
• Biological source: Staphylococcus aureus; More
• Total number of polymer chains: 6
• Total formula weight: 169715.13

Authors

Kolaric, A.,Germe, T.,Hrast, M.,Stevenson, C.E.M.,Lawson, D.M.,Burton, N.,Voros, J.,Maxwell, A.,Minovski, N.,Anderluh, M. (deposition date: 2020-05-13, release date: 2020-11-11, Last modification date: 2024-01-24)

• Primary citation: Kolaric, A.,Germe, T.,Hrast, M.,Stevenson, C.E.M.,Lawson, D.M.,Burton, N.P.,Voros, J.,Maxwell, A.,Minovski, N.,Anderluh, M.; Potent DNA gyrase inhibitors bind asymmetrically to their target using symmetrical bifurcated halogen bonds.; Nat Commun, 12:150-150, 2021; PubMed: 33420011; DOI: 10.1038/s41467-020-20405-8

Experimental method

X-RAY DIFFRACTION (2.3 Å)