6Z1A

Ternary complex of Staphylococcus aureus DNA gyrase with AMK12 and DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0003677	molecular_function	DNA binding
B	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
B	0005524	molecular_function	ATP binding
B	0006259	biological_process	DNA metabolic process
B	0006265	biological_process	DNA topological change
D	0003677	molecular_function	DNA binding
D	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
D	0005524	molecular_function	ATP binding
D	0006259	biological_process	DNA metabolic process
D	0006265	biological_process	DNA topological change

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue EPE B 1701

Chain	Residue
B	ASN1182
B	GLN1267
B	VAL1268
B	ASN1269
B	ARG1272
B	PRO1326
E	DC3
E	DC4

---

site_id	AC2
Number of Residues	6
Details	binding site for residue MN B 1702

Chain	Residue
B	ASP510
B	HOH1815
B	HOH1834
B	HOH1861
B	HOH1869
B	ASP508

---

site_id	AC3
Number of Residues	2
Details	binding site for residue DMS D 1601

Chain	Residue
D	GLN1267
F	DC4

---

site_id	AC4
Number of Residues	4
Details	binding site for residue DMS D 1602

Chain	Residue
D	ARG630
D	MET1179
D	PRO1343
D	HOH1791

---

site_id	AC5
Number of Residues	9
Details	binding site for residue EPE D 1603

Chain	Residue
D	ASN1182
D	GLN1267
D	VAL1268
D	ASN1269
D	ARG1272
D	PRO1326
D	HOH1792
F	DC3
F	DC4

---

site_id	AC6
Number of Residues	1
Details	binding site for residue CL D 1604

Chain	Residue
D	ARG1429

---

site_id	AC7
Number of Residues	6
Details	binding site for residue MN D 1605

Chain	Residue
D	GLU435
D	ASP508
D	HOH1705
D	HOH1777
F	DG8
H	DG2009

---

site_id	AC8
Number of Residues	7
Details	binding site for residue MN D 1606

Chain	Residue
D	HIS1390
D	HOH1836
D	HOH1840
D	HOH1853
E	DA1
E	HOH1702
E	HOH1707

---

site_id	AC9
Number of Residues	1
Details	binding site for residue DMS E 1601

Chain	Residue
E	DC4

---

site_id	AD1
Number of Residues	8
Details	binding site for residue Q52 G 2101

Chain	Residue
B	ASP1083
B	MET1121
D	ALA1068
D	ASP1083
G	DT2010
G	DA2011
H	DT2010
H	DA2011

---

site_id	AD2
Number of Residues	6
Details	binding site for residue MN G 2102

Chain	Residue
E	HOH1704
E	HOH1708
G	DG2009
G	HOH2201
G	HOH2204
G	HOH2208

---

Functional Information from PROSITE/UniProt

site_id	PS00177
Number of Residues	9
Details	TOPOISOMERASE_II DNA topoisomerase II signature. LVEGDSAGG

Chain	Residue	Details
B	LEU433-GLY441

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	228
Details	Domain: {"description":"Toprim","evidences":[{"source":"HAMAP-Rule","id":"MF_01898","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01898","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Site: {"description":"Interaction with DNA","evidences":[{"source":"HAMAP-Rule","id":"MF_01898","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Active site: {"description":"O-(5'-phospho-DNA)-tyrosine intermediate","evidences":[{"source":"HAMAP-Rule","id":"MF_01897","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---