6Z10
Crystal structure of a humanized (K18E, K269N) rat succinate receptor SUCNR1 (GPR91) in complex with a nanobody and antagonist
Summary for 6Z10
Entry DOI | 10.2210/pdb6z10/pdb |
Descriptor | Succinate receptor 1, Nanobody6, 2-[2-[[3-[4-chloranyl-2-fluoranyl-5-[(3~{R})-piperidin-3-yl]oxy-phenyl]-2-fluoranyl-phenyl]carbonylamino]-5-fluoranyl-phenyl]ethanoic acid, ... (7 entities in total) |
Functional Keywords | g protein-coupled receptor gpcr succinate receptor, membrane protein |
Biological source | Rattus norvegicus (Rat) More |
Total number of polymer chains | 2 |
Total formula weight | 60283.68 |
Authors | Haffke, M.,Villard, F. (deposition date: 2020-05-11, release date: 2020-09-16, Last modification date: 2024-01-24) |
Primary citation | Velcicky, J.,Wilcken, R.,Cotesta, S.,Janser, P.,Schlapbach, A.,Wagner, T.,Piechon, P.,Villard, F.,Bouhelal, R.,Piller, F.,Harlfinger, S.,Stringer, R.,Fehlmann, D.,Kaupmann, K.,Littlewood-Evans, A.,Haffke, M.,Gommermann, N. Discovery and Optimization of Novel SUCNR1 Inhibitors: Design of Zwitterionic Derivatives with a Salt Bridge for the Improvement of Oral Exposure. J.Med.Chem., 63:9856-9875, 2020 Cited by PubMed: 32856916DOI: 10.1021/acs.jmedchem.0c01020 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.269 Å) |
Structure validation
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