6Z08
Crystal structure of cAMP-dependent protein kinase A (CHO PKA) in complex with 4-Nitrophenol
Summary for 6Z08
Entry DOI | 10.2210/pdb6z08/pdb |
Descriptor | cAMP-dependent protein kinase catalytic subunit alpha, P-NITROPHENOL (3 entities in total) |
Functional Keywords | phosphotransferase, signalling pathways, glycogen metabolism, serine/threonine kinase, transferase |
Biological source | Cricetulus griseus (Chinese hamster) |
Total number of polymer chains | 1 |
Total formula weight | 41252.88 |
Authors | Oebbeke, M.,Siefker, C.,Heine, A.,Klebe, G. (deposition date: 2020-05-08, release date: 2020-12-09, Last modification date: 2024-10-09) |
Primary citation | Oebbeke, M.,Siefker, C.,Wagner, B.,Heine, A.,Klebe, G. Fragment Binding to Kinase Hinge: If Charge Distribution and Local pK a Shifts Mislead Popular Bioisosterism Concepts. Angew.Chem.Int.Ed.Engl., 60:252-258, 2021 Cited by PubMed: 33021032DOI: 10.1002/anie.202011295 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.49 Å) |
Structure validation
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