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6Z08

Crystal structure of cAMP-dependent protein kinase A (CHO PKA) in complex with 4-Nitrophenol

Summary for 6Z08
Entry DOI10.2210/pdb6z08/pdb
DescriptorcAMP-dependent protein kinase catalytic subunit alpha, P-NITROPHENOL (3 entities in total)
Functional Keywordsphosphotransferase, signalling pathways, glycogen metabolism, serine/threonine kinase, transferase
Biological sourceCricetulus griseus (Chinese hamster)
Total number of polymer chains1
Total formula weight41252.88
Authors
Oebbeke, M.,Siefker, C.,Heine, A.,Klebe, G. (deposition date: 2020-05-08, release date: 2020-12-09, Last modification date: 2024-01-24)
Primary citationOebbeke, M.,Siefker, C.,Wagner, B.,Heine, A.,Klebe, G.
Fragment Binding to Kinase Hinge: If Charge Distribution and Local pK a Shifts Mislead Popular Bioisosterism Concepts.
Angew.Chem.Int.Ed.Engl., 60:252-258, 2021
Cited by
PubMed: 33021032
DOI: 10.1002/anie.202011295
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.49 Å)
Structure validation

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