6YYZ

tRNA-Guanine Transglycosylase (TGT) labeled with 5-fluorotryptophan in co-crystallized complex with 6-amino-2-(methylamino)-4-(2-((2R,3R,4R,5R)-3,4,5-trimethoxytetrahydrofuran-2-yl)ethyl)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one

6YYZ の概要

• エントリーDOI: 10.2210/pdb6yyz/pdb
• 関連するPDBエントリー: 6YGX
• 分子名称: Queuine tRNA-ribosyltransferase, ZINC ION, 6-amino-2-(methylamino)-4-(2-((2R,3R,4R,5R)-3,4,5-trimethoxytetrahydrofuran-2-yl)ethyl)-1H-imidazo[4,5-g]quinazolin-8(7H)-one, ... (4 entities in total)
• 機能のキーワード: transferase, tgt, trna-guanine transglycosylase, guanine insertion enzyme, homodimer
• 由来する生物種: Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43625.64

構造登録者

Nguyen, A.,Heine, A.,Klebe, G. (登録日: 2020-05-06, 公開日: 2020-05-13, 最終更新日: 2024-01-24)

• 主引用文献: Nguyen, A.,Heine, A.,Klebe, G.; Co-crystallization, 19F NMR and nanoESI-MS reveal dimer disturbing inhibitors and conformational changes at dimer contacts; To Be Published,

実験手法

X-RAY DIFFRACTION (1.21 Å)