6YXV

FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH N-Methyl-N-{3-[(2-phenylamino-5-trifluoromethyl-pyrimidin-4-ylamino)-methyl]-pyridin-2-yl}-methanesulfonamide

Summary for 6YXV

Entry DOI	10.2210/pdb6yxv/pdb
Descriptor	Focal adhesion kinase 1, ~{N}-methyl-~{N}-[3-[(~{E})-[2-phenylazanyl-5-(trifluoromethyl)pyrimidin-4-yl]iminomethyl]pyridin-2-yl]methanesulfonamide, SULFATE ION, ... (4 entities in total)
Functional Keywords	protein tyrosine kinase, atp binding, transferase, transferase-inhibitor complex
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	131114.70
Authors	Musil, D.,Heinrich, T.,Amaral, M. (deposition date: 2020-05-04, release date: 2021-02-10, Last modification date: 2024-01-24)
Primary citation	Berger, B.T.,Amaral, M.,Kokh, D.B.,Nunes-Alves, A.,Musil, D.,Heinrich, T.,Schroder, M.,Neil, R.,Wang, J.,Navratilova, I.,Bomke, J.,Elkins, J.M.,Muller, S.,Frech, M.,Wade, R.C.,Knapp, S. Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2. Cell Chem Biol, 28:686-, 2021 Cited by PubMed: 33497606 DOI: 10.1016/j.chembiol.2021.01.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.298 Å)

Structure validation