6YXV

FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH N-Methyl-N-{3-[(2-phenylamino-5-trifluoromethyl-pyrimidin-4-ylamino)-methyl]-pyridin-2-yl}-methanesulfonamide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0004713	molecular_function	protein tyrosine kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
C	0004672	molecular_function	protein kinase activity
C	0004713	molecular_function	protein tyrosine kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
D	0004672	molecular_function	protein kinase activity
D	0004713	molecular_function	protein tyrosine kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue Q2H A 701

Chain	Residue
A	ILE428
A	ARG550
A	ASN551
A	LEU553
A	GLY563
A	ASP564
A	LEU567
A	SER568
A	GLU430
A	VAL436
A	ALA452
A	VAL484
A	MET499
A	GLU500
A	LEU501
A	CYS502

---

site_id	AC2
Number of Residues	15
Details	binding site for residue Q2H B 701

Chain	Residue
B	ARG426
B	GLU430
B	ALA452
B	VAL484
B	MET499
B	GLU500
B	LEU501
B	CYS502
B	GLY505
B	ASN551
B	LEU553
B	GLY563
B	ASP564
B	LEU567
B	SER568

---

site_id	AC3
Number of Residues	4
Details	binding site for residue SO4 B 702

Chain	Residue
B	SER601
B	ARG668
C	SER601
C	ARG668

---

site_id	AC4
Number of Residues	15
Details	binding site for residue Q2H C 701

Chain	Residue
C	ARG426
C	ILE428
C	GLU430
C	VAL436
C	ALA452
C	MET499
C	GLU500
C	CYS502
C	GLY505
C	ASN551
C	LEU553
C	GLY563
C	ASP564
C	LEU567
C	SER568

---

site_id	AC5
Number of Residues	13
Details	binding site for residue Q2H D 701

Chain	Residue
D	ILE428
D	VAL436
D	MET499
D	GLU500
D	LEU501
D	CYS502
D	GLY505
D	ASN551
D	LEU553
D	GLY563
D	ASP564
D	LEU567
D	SER568

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	27
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGQFGDVHqGiymspenpala.......VAIK

Chain	Residue	Details
A	ILE428-LYS454

---

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FVHrDIAARNVLV

Chain	Residue	Details
A	PHE542-VAL554

---

site_id	PS00661
Number of Residues	31
Details	FERM_2 FERM domain signature 2. HrdiaarnvlVSsndCVklgDfgLsrYMeDS

Chain	Residue	Details
A	HIS544-SER574

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12467573","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---