6YW4

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with N-oxalylglycine (NOG) and a RaPID-derived silent allosteric cyclic peptide 3C (14-mer)

6YW4 の概要

• エントリーDOI: 10.2210/pdb6yw4/pdb
• 関連するPDBエントリー: 5L9B 5L9R 5L9V 6YW1 6YW2 6YW3
• 分子名称: Egl nine homolog 1, PHD2-SPECIFIC RaPID CYCLIC PEPTIDE 3C (14-MER), MANGANESE (II) ION, ... (6 entities in total)
• 機能のキーワード: oxidoreductase, non-heme dioxygenase, iron, 2-oxoglutarate, hypoxia-inducible factor, hif, hif prolyl hydroxylase domain 2, phd2, egln1, oxygenase, hypoxia, dna-binding, metal-binding, transcription, helix-loop-helix-beta, dsbh, facial triad, cytoplasm, transcription/epigenetic regulation, signaling, development, cell structure, beta-hydroxylation, transcription activator/inhibitor, ubl conjugation, polymorphism, vitamin c, zinc-finger, familial erythrocytosis, breast cancer, transcription complex
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28113.60

構造登録者

Chowdhury, R.,Schofield, C.J. (登録日: 2020-04-29, 公開日: 2020-12-30, 最終更新日: 2024-01-24)

• 主引用文献: Chowdhury, R.,Abboud, M.I.,McAllister, T.E.,Banerji, B.,Bhushan, B.,Sorensen, J.L.,Kawamura, A.,Schofield, C.J.; Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2.; Sci Rep, 10:21964-21964, 2020; PubMed: 33319810; DOI: 10.1038/s41598-020-76307-8

実験手法

X-RAY DIFFRACTION (1.528 Å)