6YW4
HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with N-oxalylglycine (NOG) and a RaPID-derived silent allosteric cyclic peptide 3C (14-mer)
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue MN A 501 |
| Chain | Residue |
| A | HIS313 |
| A | ASP315 |
| A | HIS374 |
| A | OGA502 |
| A | HOH621 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | binding site for residue OGA A 502 |
| Chain | Residue |
| A | TYR329 |
| A | HIS374 |
| A | VAL376 |
| A | ARG383 |
| A | MN501 |
| A | HOH614 |
| A | HOH620 |
| A | HOH621 |
| A | HOH635 |
| A | HOH666 |
| A | MET299 |
| A | TYR310 |
| A | HIS313 |
| A | ASP315 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 503 |
| Chain | Residue |
| A | ILE292 |
| A | GLY294 |
| A | LYS337 |
| A | TYR390 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 504 |
| Chain | Residue |
| A | PRO189 |
| A | ALA190 |
| A | HOH602 |
| A | HOH604 |
| B | ARG12 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16782814, ECO:0000269|PubMed:19604478, ECO:0000269|PubMed:28594552, ECO:0007744|PDB:2G19, ECO:0007744|PDB:3HQU, ECO:0007744|PDB:5V18 |
| Chain | Residue | Details |
| A | HIS313 | |
| A | ASP315 | |
| A | HIS374 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:19604478 |
| Chain | Residue | Details |
| A | ARG383 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 5 |
| Details | MOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:21601578 |
| Chain | Residue | Details |
| A | ALA201 | |
| A | CYS208 | |
| A | CYS302 | |
| A | CYS323 | |
| A | CYS326 |
