6YVY

FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH 4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide

6YVY の概要

• エントリーDOI: 10.2210/pdb6yvy/pdb
• 分子名称: Focal adhesion kinase 1, 4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: protein tyrosine kinase, atp binding, transferase, transferase-inhibitor complex
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 131146.95

構造登録者

Musil, D.,Amaral, M. (登録日: 2020-04-28, 公開日: 2021-02-10, 最終更新日: 2024-01-24)

• 主引用文献: Berger, B.T.,Amaral, M.,Kokh, D.B.,Nunes-Alves, A.,Musil, D.,Heinrich, T.,Schroder, M.,Neil, R.,Wang, J.,Navratilova, I.,Bomke, J.,Elkins, J.M.,Muller, S.,Frech, M.,Wade, R.C.,Knapp, S.; Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2.; Cell Chem Biol, 28:686-, 2021; PubMed: 33497606; DOI: 10.1016/j.chembiol.2021.01.003

実験手法

X-RAY DIFFRACTION (1.918 Å)