6YV3

Structure of recombinant human beta-glucocerebrosidase in complex with galacto-configured cyclophellitol aziridine inhibitor

This is a non-PDB format compatible entry.

Summary for 6YV3

• Entry DOI: 10.2210/pdb6yv3/pdb
• Related: 6YTP 6YTR 6YUT
• Descriptor: Glucosylceramidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• Functional Keywords: beta-glucocerebrosidase, lysosomal glycoside hydrolase, gh30, hydrolase, cyclophellitol aziridine, inhibitor, complex
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 115729.28

Authors

Rowland, R.J.,Davies, G.J. (deposition date: 2020-04-27, release date: 2021-05-12, Last modification date: 2024-01-24)

• Primary citation: Rowland, R.J.,Chen, Y.,Breen, I.,Wu, L.,Offen, W.A.,Beenakker, T.J.,Su, Q.,van den Nieuwendijk, A.M.C.H.,Aerts, J.M.F.G.,Artola, M.,Overkleeft, H.S.,Davies, G.J.; Design, Synthesis and Structural Analysis of Glucocerebrosidase Imaging Agents.; Chemistry, 27:16377-16388, 2021; PubMed: 34570911; DOI: 10.1002/chem.202102359

Experimental method

X-RAY DIFFRACTION (1.8 Å)