6YV3
Structure of recombinant human beta-glucocerebrosidase in complex with galacto-configured cyclophellitol aziridine inhibitor
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | AAA, BBB | Glucosylceramidase | polymer | 497 | 55640.2 | 2 | UniProt (P04062) Pfam (PF02055) Pfam (PF17189) In PDB | Homo sapiens (Human) | Acid beta-glucosidase,Alglucerase,Beta-glucocerebrosidase,Beta-GC,D-glucosyl-N-acylsphingosine glucohydrolase,Imiglucerase |
| 2 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 3 | AAA, BBB | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 4 | BBB, AAA | SULFATE ION | non-polymer | 96.1 | 14 | Chemie (SO4) | |||
| 5 | BBB, AAA | 1,2-ETHANEDIOL | non-polymer | 62.1 | 14 | Chemie (EDO) | |||
| 6 | BBB, AAA | (1S,2S,3S,4S,5R,6R)-5-amino-6-(hydroxymethyl)cyclohexane-1,2,3,4-tetrol | non-polymer | 193.2 | 2 | Chemie (UUU) | |||
| 7 | BBB | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 8 | BBB | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 9 | water | water | 18.0 | 855 | Chemie (HOH) |
Sequence modifications
AAA, BBB: 1 - 497 (UniProt: P04062)
| PDB | External Database | Details |
|---|---|---|
| His 495 | Arg 534 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 111280.3 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 848.8 | |
| Non-Polymers* | Number of molecules | 36 |
| Total formula weight | 3600.1 | |
| All* | Total formula weight | 115729.3 |
