6YTM

Human Brd2(BD2) L383V mutant in complex with ET-JQ1-OMe

Summary for 6YTM

Entry DOI	10.2210/pdb6ytm/pdb
Descriptor	Bromodomain-containing protein 2, methyl (2R)-2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]butanoate, (2S)-1-[3-{[(2R)-2-hydroxypropyl]oxy}-2,2-bis({[(2R)-2-hydroxypropyl]oxy}methyl)propoxy]propan-2-ol, ... (4 entities in total)
Functional Keywords	epigenetics, bump and hole, brd2, second bromodomain, transcription
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	28345.62
Authors	Bond, A.G.,Ciulli, A.,Cowan, A.D. (deposition date: 2020-04-24, release date: 2020-05-27, Last modification date: 2024-01-24)
Primary citation	Bond, A.G.,Testa, A.,Ciulli, A. Stereoselective synthesis of allele-specific BET inhibitors. Org.Biomol.Chem., 18:7533-7539, 2020 Cited by PubMed: 32756710 DOI: 10.1039/d0ob01165g PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.56 Å)

Structure validation