6YSC

GLYCOSYLATED KNOB-HOLE/DUMMY FC FRAGMENT

6YSC の概要

• エントリーDOI: 10.2210/pdb6ysc/pdb
• 分子名称: Immunoglobulin gamma-1 heavy chain, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: bispecific antibody, fc engineering, knob-into-hole, force, format chain exchange, immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 55511.19

構造登録者

Kuglstatter, A.,Leibrock, L.,Benz, J. (登録日: 2020-04-22, 公開日: 2020-10-14, 最終更新日: 2024-01-24)

• 主引用文献: Dengl, S.,Mayer, K.,Bormann, F.,Duerr, H.,Hoffmann, E.,Nussbaum, B.,Tischler, M.,Wagner, M.,Kuglstatter, A.,Leibrock, L.,Buldun, C.,Georges, G.,Brinkmann, U.; Format chain exchange (FORCE) for high-throughput generation of bispecific antibodies in combinatorial binder-format matrices.; Nat Commun, 11:4974-4974, 2020; PubMed: 33009381; DOI: 10.1038/s41467-020-18477-7

実験手法

X-RAY DIFFRACTION (2.05 Å)