6YPP

Crystal structure of the cAMP-dependent protein kinase A cocrystallized with PKI (5-24). Soaking of aminofasudil and displacing it with the fragment isoquinoline.

Summary for 6YPP

• Entry DOI: 10.2210/pdb6ypp/pdb
• Descriptor: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, ISOQUINOLINE, ... (4 entities in total)
• Functional Keywords: phosphotransferase, signalling pathways, glycogen metabolism, serine/threonine kinase, transferase
• Biological source: Cricetulus griseus (Chinese hamster); More
• Total number of polymer chains: 2
• Total formula weight: 43469.34

Authors

Oebbeke, M.,Gerber, H.-D.,Heine, A.,Klebe, G. (deposition date: 2020-04-16, release date: 2021-04-28, Last modification date: 2024-01-24)

• Primary citation: Oebbeke, M.,Hassaan, E.,Heine, A.,Klebe, G.; Fluorescence-based displacement experiments; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.75 Å)