6YNP

Crystal structure of YTHDC1 with compound T96C1

Summary for 6YNP

• Entry DOI: 10.2210/pdb6ynp/pdb
• Descriptor: YTHDC1, ~{N}-methylpyridine-3-carboxamide, SULFATE ION, ... (5 entities in total)
• Functional Keywords: ythdc1, m6a, complex, inhibitor, rna binding protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 42914.52

Authors

Bedi, R.K.,Huang, D.,Wiedmer, L.,Caflisch, A. (deposition date: 2020-04-14, release date: 2020-07-15, Last modification date: 2024-01-24)

• Primary citation: Li, Y.,Bedi, R.K.,Nai, F.,von Roten, V.,Dolbois, A.,Zalesak, F.,Nachawati, R.,Huang, D.,Caflisch, A.; Structure-based design of ligands of the m6A-RNA reader YTHDC1; Eur J Med Chem Rep, 5:100057-, 2022; DOI: 10.1016/j.ejmcr.2022.100057

Experimental method

X-RAY DIFFRACTION (1.1 Å)