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6YNP

Crystal structure of YTHDC1 with compound T96C1

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
B0003723molecular_functionRNA binding
Functional Information from PDB Data
site_idAC1
Number of Residues9
Detailsbinding site for residue PJH A 601
ChainResidue
AASN367
ATRP377
ASER378
ATHR379
ALEU380
ATRP428
AMET434
AASP476
AHOH776

site_idAC2
Number of Residues7
Detailsbinding site for residue SO4 A 602
ChainResidue
AGLY344
ATHR345
ASER346
ALYS347
AHOH737
AHOH875
AHOH884

site_idAC3
Number of Residues3
Detailsbinding site for residue SO4 A 603
ChainResidue
AHIS420
AHIS421
AHOH718

site_idAC4
Number of Residues11
Detailsbinding site for residue SO4 A 604
ChainResidue
ATRP465
AGLN478
AGLU479
AHOH735
AHOH765
AHOH787
AHOH794
AHOH807
AHOH903
AHOH904
BLYS347

site_idAC5
Number of Residues7
Detailsbinding site for residue SO4 A 605
ChainResidue
ALYS361
AARG404
AGLY474
AARG475
AASP476
AHOH738
AHOH782

site_idAC6
Number of Residues9
Detailsbinding site for residue PJH B 601
ChainResidue
BASN367
BTRP377
BSER378
BTHR379
BLEU380
BTRP428
BASP476
BHOH701
BHOH861

site_idAC7
Number of Residues7
Detailsbinding site for residue SO4 B 602
ChainResidue
BARG451
BGLU452
BHOH753
BHOH767
BHOH772
BHOH782
BHOH807

site_idAC8
Number of Residues7
Detailsbinding site for residue SO4 B 603
ChainResidue
BSER419
BHIS420
BHIS421
BARG451
BHOH801
BHOH869
BHOH876

site_idAC9
Number of Residues6
Detailsbinding site for residue SO4 B 604
ChainResidue
BARG404
BARG475
BASP476
BHOH720
BHOH733
BHOH770

site_idAD1
Number of Residues6
Detailsbinding site for residue CL B 605
ChainResidue
BARG356
BPHE357
BTRP465
BGLU479
BILE480
BHOH873

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:31670957, ECO:0007744|PDB:6RT4, ECO:0007744|PDB:6RT5, ECO:0007744|PDB:6RT6, ECO:0007744|PDB:6RT7
ChainResidueDetails
ALYS361
AASP476
BLYS361
BASP476

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:25242552, ECO:0000269|PubMed:31670957, ECO:0007744|PDB:6RT4, ECO:0007744|PDB:6RT5, ECO:0007744|PDB:6RT6, ECO:0007744|PDB:6RT7
ChainResidueDetails
ATRP377
BTRP377

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:25242552
ChainResidueDetails
ATRP428
BTRP428

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER424
BSER424

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231
ChainResidueDetails
ASER435
BSER435

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PDB entries from 2024-10-30

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