6YLL
Biochemical, Cellular and Structural Characterization of Novel ERK3 Inhibitors
Summary for 6YLL
Entry DOI | 10.2210/pdb6yll/pdb |
Descriptor | Mitogen-activated protein kinase 6, ~{N}4-[3-(4-methoxyphenyl)-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl]cyclohexane-1,4-diamine (3 entities in total) |
Functional Keywords | human mitogen activated protein kinase 6 (mapk6), erk3, inhibitor, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 72726.74 |
Authors | Graedler, U. (deposition date: 2020-04-07, release date: 2020-09-23, Last modification date: 2024-01-24) |
Primary citation | Gradler, U.,Busch, M.,Leuthner, B.,Raba, M.,Burgdorf, L.,Lehmann, M.,Linde, N.,Esdar, C. Biochemical, cellular and structural characterization of novel and selective ERK3 inhibitors. Bioorg.Med.Chem.Lett., 30:127551-127551, 2020 Cited by PubMed: 32927028DOI: 10.1016/j.bmcl.2020.127551 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.89 Å) |
Structure validation
Download full validation report