6YLL
Biochemical, Cellular and Structural Characterization of Novel ERK3 Inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Mitogen-activated protein kinase 6 | polymer | 319 | 36193.7 | 2 | UniProt (Q16659) Pfam (PF00069) | Homo sapiens (Human) | MAPK 6,Extracellular signal-regulated kinase 3,ERK-3,MAP kinase isoform p97,p97-MAPK |
| 2 | C (A) | ~{N}4-[3-(4-methoxyphenyl)-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl]cyclohexane-1,4-diamine | non-polymer | 339.4 | 1 | Chemie (OYB) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 26 | Chemie (HOH) |
Sequence modifications
A, B: 9 - 327 (UniProt: Q16659)
| PDB | External Database | Details |
|---|---|---|
| Val 290 | Leu 290 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 72387.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 339.4 | |
| All* | Total formula weight | 72726.7 |
