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6YLL

Biochemical, Cellular and Structural Characterization of Novel ERK3 Inhibitors

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Mitogen-activated protein kinase 6polymer31936193.72UniProt (Q16659)
Pfam (PF00069)
Homo sapiens (Human)MAPK 6,Extracellular signal-regulated kinase 3,ERK-3,MAP kinase isoform p97,p97-MAPK
2C
(A)
~{N}4-[3-(4-methoxyphenyl)-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl]cyclohexane-1,4-diaminenon-polymer339.41Chemie (OYB)
3D, E
(A, B)
waterwater18.026Chemie (HOH)
Sequence modifications
A, B: 9 - 327 (UniProt: Q16659)
PDBExternal DatabaseDetails
Val 290Leu 290engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight72387.3
Non-Polymers*Number of molecules1
Total formula weight339.4
All*Total formula weight72726.7
*Water molecules are not included.

243531

PDB entries from 2025-10-22

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