6YLC

Biochemical, Cellular and Structural Characterization of Novel ERK3 Inhibitors

6YLC の概要

• エントリーDOI: 10.2210/pdb6ylc/pdb
• 関連するPDBエントリー: 6YKY
• 分子名称: Mitogen-activated protein kinase 6, 5-fluoranyl-2-[5-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]benzenecarbonitrile (3 entities in total)
• 機能のキーワード: human mitogen activated protein kinase 6 (mapk6), erk3, inhibitor, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 146448.41

構造登録者

Graedler, U. (登録日: 2020-04-07, 公開日: 2020-09-23, 最終更新日: 2024-01-24)

• 主引用文献: Gradler, U.,Busch, M.,Leuthner, B.,Raba, M.,Burgdorf, L.,Lehmann, M.,Linde, N.,Esdar, C.; Biochemical, cellular and structural characterization of novel and selective ERK3 inhibitors.; Bioorg.Med.Chem.Lett., 30:127551-127551, 2020; PubMed: 32927028; DOI: 10.1016/j.bmcl.2020.127551

実験手法

X-RAY DIFFRACTION (2.43 Å)